Those entering Thessaloniki from the west can take the 3, 5, 6, 12, 39 or 33 bus and get off at "Mitropoli" stop. Coming from the east, one can take the 3, 5, 6, 12, 33 or 39 bus and get off at "Agias Sofas" stop on Tsimiski street.

There is no free parking available near the Museum however you can pay to park your car in several parking lots in the area.